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The protein encoded by this gene is involved in antibody and T-cell receptor V D J recombination. Because of these effects, Rag1 deletion is used in mouse models of disease to impair T cell and B cell development, and functionally deletes mature T and B cells from the immune system. In humans, RAG deficiency was first recognised as a form of immune dysregulation known as Omenn syndrome.
RAG deficiency is considered an autosomal recessive disease. The disorder is generally identified in infants. However, top To Be With You - Various - Car Classics 2.0 variants have been ranked by their predicted clinical relevance.
From Wikipedia, the free encyclopedia. Chromosome 11 human Rag Ar Plinn - Skeduz - Rag Ar Plinn. National Center for Biotechnology Information, U. National Library of Medicine. August Journal of Clinical Immunology. Kuby Immunology. New York: W. Freeman and Company. Jackson Laboratories. May The New England Journal of Medicine. November The Journal of Clinical Investigation. June The Journal of Allergy and Clinical Immunology. April February Categories : Genes on human chromosome 11 Human chromosome 11 gene stubs.
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